Old biomed tab dump

Donor eggs (sort of) for mitochondrial defects BBC NEWS | Health

The genetic fault is contained in structures in the egg called the mitochondria, which are involved in maintaining the egg’s internal processes.

If an egg with faulty mitochondria is fertilised the resulting child could have any of hundreds of different diseases including anaemia, dementia, hypertension and a range of neurological disorders.

Previous failures

US researchers have previously tried and failed to correct this defect by adding healthy donated mitochondria into the eggs of patients wishing to have children.

But these attempts resulted in birth defects – probably because mitochondria are so delicate that they are damaged when they are transplanted from one egg to another.

PLoS Biology: Reawakening Retrocyclins: Ancestral Human Defensins Active Against HIV-1

Our study reveals for the first time, to our knowledge, that human cells have the ability to make cyclic theta-defensins. Given this evidence that human cells could make theta-defensins, we attempted to restore endogenous expression of retrocyclin peptides. Since human theta-defensin genes are transcribed, we used aminoglycosides to read-through the premature termination codon found in the mRNA transcripts. This treatment induced the production of intact, bioactive retrocyclin-1 peptide by human epithelial cells and cervicovaginal tissues. The ability to reawaken retrocyclin genes from their 7 million years of slumber using aminoglycosides could provide a novel way to secure enhanced resistance to HIV-1 infection.

Brain radiotherapy affects mind [confirming something everyone who has known a bain-irradiated patient already knew]

It is known that radiation treatment in the brain causes some damage to normal tissue and the study’s researchers suspected it could lead to decline in mental function.

A previous study in the same patients done six years after treatment found no difference in aspects like memory, attention and the speed at which people could process information, in those who had received radiotherapy.

But the latest research, carried out more than a decade after original treatment, did find significant variation in the results of several mental tests between those who had had radiotherapy and those who had not.

In all, 53% of patients who had radiotherapy showed decline in brain function compared with 27% of patients who only had surgery.

The most profound differences were in tests to measure attention

This Blue Rat May Have the Secret to Avoid Spinal Cord Injuries – Blue dye – Gizmodo

That secret is Brilliant Blue G dye, a variant of Blue Number One, which is a common and harmless food coloring product. Scientists dropped weights on the rats’ backs to break their little spinal cords, injecting the Brilliant Blue G dye in their bodies. The dye turned their skins blue, but within weeks all motor functions returned to normal. The rat could walk, run, jump, have sex, and do whatever it wanted.

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